Ovarian Cancer Stem Cells: A New Target for Cancer Therapy
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Ovarian Cancer Stem Cells: A New Target for Cancer Therapy
Ovarian cancer is a highly lethal disease among all gynecologic malignancies and is the fifth leading cause of cancer-related death in women. Although the standard combination of surgery and chemotherapy was initially effective in patients with ovarian cancer, disease relapse commonly occurred due to the generation of chemoresistance. It has been reported that cancer stem cells (CSCs) are invol...
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Glioblastoma is a destructive form of brain tumor that kills most patients within two years of diagnosis.Treatments for glioblastoma include the usual options of surgery, radiation therapy and chemotherapy, but there is no effective treatment. The tumors are capable of spreading tendrils out into the brain and it can grow back in a matter of months after being removed. The cancer stem cell...
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Adult stem cells have recently been identified in several types of mature tissue and it has also been suggested that stem-like cells exist in cancerous tissues. In this regard, stem-like cell subpopulations, referred to as side-population (SP) cells, have been identified in several tissue and tumor types, based on their ability to remove intracellular Hoechst 33342, a fluorescent dye. We have i...
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Within a single tumor clone, cells have significantly different abilities to proliferate and form new tumors. This has led to the hypothesis that most cells in a cancer have a limited ability to divide and only a small subset of distinct cells, the cancer stem cells (CSCs), has the capacity to self-renew and form new tumors . It has been proposed that the development of tumors is based exclusiv...
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ژورنال
عنوان ژورنال: BioMed Research International
سال: 2013
ISSN: 2314-6133,2314-6141
DOI: 10.1155/2013/916819